 Over the past several decades, the global population has grown exponentially while human activities have had a profound effect on terrestrial water fluxes. This has resulted in significant changes to hydrological processes, ranging from local to global levels. To address these changes, the first global water resource assessment was conducted in the early 1990s, followed by the development of large-scale hydrological models, LHMs, which began to consider the interaction between terrestrial water fluxes and human activities such as water use and reservoir regulation. Since then, more and more LHMs have included human impacts on the hydrological cycle, but the representation of human activities remains a challenge. In this paper, we review the progress made in developing and applying human impact modeling in LHMs, highlighting some of the key challenges and suggesting possible improvements. This article was authored by Waiwata, Waiwata, MFP Birkins, and others.