Reporter movement from ER to Golgi of mock-treated and huntingtin-depleted cells

The Company of Biologists
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Published on Dec 9, 2014

HeLa C1 cells either mock or HTT siRNA treated were imaged by live-cell spinning-disk microscopy after ligand addition. Interestingly, huntingtin depletion led to a significant reduction (~45%) in ER-to-Golgi transport, suggesting a kinetic delay rather than a complete block of cargo transfer from the ER to the Golgi. The related Research Article by Hemma Brandstaetter, Antonina J. Kruppa and Folma Buss can be read for free at http://dmm.biologists.org/content/7/1...

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