 Spinal cord injuries can cause severe physical and psychological impairments, leading to a wide range of complications. These complications are often due to secondary injuries, which are triggered by the primary injury and involve multiple systems of the body. Research into psychoneuroimmiginemia has revealed that these secondary injuries are closely linked to the patient's mental state and overall health. By understanding the complex interactions between the various systems involved, it may be possible to develop more effective treatments for spinal cord injury patients. This article was authored by Miguel A. Ortiga, Oscar Frail Martinez, Cielo Garcia Montero, and others.