 1. The COVID-19 pandemic is caused by the RNA coronavirus SARS-CoV-2, which has a high mutation rate compared to its hosts. 2. The mutagenic capability of SARS-CoV-2 depends on several factors, including the fidelity of viral enzymes that replicate nucleic acids, such as the RNA-dependent RNA polymerase, RhoDARP. 3. We analyzed 220 genomic sequences from the desired database derived from patients infected by SARS-CoV-2 worldwide from December 2019 to mid-March 2020, and found 8 novel recurrent mutations of SARS-CoV-2. 4. Mutations in positions 2891, 3036, 14408, 23403, and 28881, are predominantly observed in Europe, while those located at positions 17746, 17857, and 18,060 are exclusively present in North America. 5. We noticed a silent mutation in the RhoDARP. This article was authored by Maria Pichetti, Brunamarini, Francesca Bernadetti, and others. We are article.tv, links in the description below.