 Noble metal nanoparticles, MNPs, have been widely used in biosensors due to their unique properties such as high surface area, catalytic activity, and biocompatibility. They can be used alone or in combination with other nanostructures to improve sensor performance. Recent developments in MNP-based biosensors have focused on improving sensitivity, selectivity, and stability. This article was authored by Meleksad Hedi, Sahandi Zangabad Param, Mirshakari Hamed, and others.