 This research paper examines the use of Serium Oxide nanoparticles, COMPS, as a potential therapy for Parkinson's disease, PD. It evaluates the antioxidant potential of the COMPS in vitro, the penetration and local toxicity of the particles in goat nasal mucosa, and the acute local toxicity of intranasal COMPS in rats. Additionally, it demonstrates the targeted brain delivery of intranasal COMPS in a rat model of PD and evaluates its efficacy through behavioral tests and histological analysis. The results suggest that intranasal COMPS are safe and effective for the management of PD. This article was authored by Muhammad, Ruj Ahmed Khan, Muserat Hussein Worsi, and others.