 Micro and nanotechnology have revolutionized the healthcare industry over the past two centuries. From Edward Jenner's use of cowpox virus in 1798 to the development of SARS-CoV-2 vaccines in 2020, the field has seen tremendous progress. Despite some setbacks, such as the bankruptcy of bind therapeutics and the suspension of doxel production, the field continues to advance new and innovative platforms that have transformed therapies, vaccines, and imaging. This article was authored by Rebecca T. Steeple, Eliza Duggan, Cole J. Batty, and others.