 This retrospective cohort study found that non-carboponam antibiotics such as Pippuricillin-Tazobactam, PTZ, and Cephapeme, FEP, were equally effective at treating extended spectrum beta-lactamase-producing enterobacterals bloodstream infections, ESB-LEBSIs. There was no significant difference in mortality rates between the two groups, suggesting that these drugs may be viable alternatives to carboponams for treating ESB-LEBSIs.