 The paper discusses how the formation of mitochondria Christi, which contain the respiratory chain, is associated with the transcriptional upregulation of genes related to oxidative phosphorylation, oxpose. The authors also identify a role for motif 1, binding protein, M1BP, which is involved in the transcriptional regulation of these genes. Without M1BP, the quantity of assembled mitochondrial respiratory complexes is reduced, leading to aggregation of the proteins in the mitochondrial matrix. This causes the mitochondrion to form multiple layers of the inner mitochondrial membrane, which is a previously unreported stress response mechanism. This article was authored by Gabriela Polyasikova, Marine Bathers, Thomas Rival, and others.