 This paper provides a comprehensive review of career development programs for junior investigators at academic health centers with clinical and translational science awards, CTSA. It outlines five key areas of focus for junior investigator career development, self-awareness, selecting the right topic and securing funding, getting adequate support, working with others and managing oneself, one's career and one's demands. These areas are essential for junior investigators to develop the necessary skills to succeed in their careers. This article was authored by Doris McGotland-Rubio, Georgiana F.W.B. Robinson, Janis Kaprolov and others.