 This study explores the correlation of disulfid ptosis with clinical prognosis, immune cell infiltration, and immunotherapy response in glioma using a risk score model developed from three disulfid ptosis-related genes. The results suggest that low-risk patients exhibit favorable prognosis and the disulfid ptosis-related signature significantly correlates with clinical pathological properties, molecular subtypes, and immunosuppressive microenvironment of glioma patients. This article was authored by Xiong Wang, Chichu and Yang, Fengjie Yang, and others.