 Macrobiotic diets have been described by the American Medical Association as one of the most dangerous dietary regiments posing not only serious hazards to the health of the individual, but even to life itself. After all, macrobiotic diets are predominately vegetarian, with a great emphasis placed on whole grains. What's wrong with that? Well, they also used to tell people to not drink water, which isn't good, and to avoid fruit. So much so, it's resulted in modern-day cases of scurvy. Now, thankfully, the macrobiotic diet has evolved over the past 30 years. This is the more kind of contemporary version in emphasis on whole grains, vegetables, and beans, while minimizing most meat, eggs, and dairy. I don't like them restricting fruits, don't like all the added salt, but compared to the standard American diet, it's got a lot of things going for it. Only a quarter of the saturated fat intake, less than half of the sugar intake, a very respectable fiber intake, two and a half times the national average, but actually taking in more sodium. So while the macrobiotic diet is an anti-inflammatory diet, it has a negative dietary inflammatory index score, as opposed to the pro-inflammatory American diet. Some of the most anti-inflammatory foods are herbs and spices. So instead of adding all that sea salt and soy sauce, the macrobiotic diet could be improved by using natural seasonings instead. Okay, but has the macrobiotic diet ever been put to the test? Yes, for diabetes. The restriction on water probably wouldn't help, as higher plain water consumption is associated with lower type 2 diabetes risk, though part of that may be because they're drinking less soda, and fruit restriction is probably not helpful, since fruit consumption is associated with significantly reduced risk of type 2 diabetes as well. But hey, same with green leafy vegetables, which is where the macrobiotic diet can really shine. It includes lots of greens. Look, you can do randomized double blind placebo-controlled crossover studies of kale, and show that it suppresses the after a meal increase in blood sugars. Eat a meal of white rice, chicken and eggs, and get a big spike in blood sugar, though significantly less, adding just a tablespoon of dried kale powder. As opposed to some kind of placebo powder, though the effect is visually exaggerated by their Y-axis shenanigans. And macrobiotic diets use whole grains, which can significantly improve insulin sensitivity compared to refined grains, which may be due in part to all the wonderful things fiber can do to help our gut bacteria thrive, which could potentially lower inflammation and decrease diabetes risk. But you don't know until you put it to the test. Just three weeks on a strictly plant-based diet, composed mostly of whole grains, vegetables, and beans, and they got about a 10% drop in blood pressure, or a whopping 35% drop in LDL-Bad cholesterol, and a 38% drop in fasting blood sugars in just 21 days. Were these changes statistically significant? Here are some three-month P-values for you. Those are my kind of P-values. In other words, yes, the changes were significant in every possible way. Similarly, short-term interventional studies on diabetics, with the so-called MA-P2 macrobiotic diets, have been performed across four continents. The MA-P comes from the guy that came up with the diet, Mario Pienisi, a strictly plant-based diet, based mostly on whole grains and vegetables, with legumes and some seeds, and decaf green tea as the preferred beverage. Look at these extraordinary numbers. A near 40% drop in fasting blood sugars, near a 27% drop in LDL cholesterol in 21 days. Now, they did lose weight, a few pounds a week, but those kinds of results were way more than one would expect with weight loss. And here's the kicker. That 40% drop in blood sugars was after cutting their insulin in half, so those numbers greatly underestimate the effects. Better results on fewer drugs. That's the power of plants. All we need now is a randomized control clinical trial to really seal the deal, which we'll cover next.