 This review paper examines the potential of novel synthetic and semi-synthetic compounds as antibacterial agents that target virulence factors in resistant strains. It focuses on research conducted in the past five years and explores a variety of compounds such as azoles, indoles, theophines, glycopeptides, plurimutilin derivatives, lactones, and calcones. These compounds can target virulence factors, which are essential for bacteria's survival and pathogenicity, but not for growth. Targeting these factors could help reduce the severity of bacterial infections while avoiding the development of resistance. The review also discusses the mechanisms of action of each compound and its potential as an antibacterial agent. The authors conclude that novel synthetic and semi-synthetic compounds offer great promise in combating antibiotic resistance and should be further studied. This article was authored by Dejan Stojkovich, Jovana Petrovich, Tamara Kareevich, and others.