 Magnesium-based hydride alloys have the potential to be used as a viable alternative to traditional hydrogen storage materials, due to their high hydrogen storage capacity, abundance, and low cost. However, slow kinetics and stable thermodynamics have limited their practical applications. In contrast to the significant progress made in enhancing the hydrogenation-slash-dehydrogenation kinetics, thermodynamic tuning remains a major challenge for MG-based alloys. Current strategies for achieving thermodynamic tuning include alloying, nano-structuring, and changing the reaction pathway. While these methods have improved the thermodynamics of MG-based alloys, they are not yet sufficient for practical application. To achieve more effective thermodynamic tuning, researchers should focus on finding reversible systems with high hydrogen capacity and tailoring the reaction enthalpies. This article was authored by Min Zhu, Yin Shan Lu, Lu Zhang Ouyang, and others.