 macrophages secrete chemicals that affect the expression of certain genes in adipocytes. This study found that exposure to these chemicals increased the expression of some genes involved in sensing fatty acids, while decreasing the expression of other genes involved in sensing omega-3 polyunsaturated fats. The results suggest that macrophage secretions could play a role in the development of inflammation in obese individuals. This article was authored by Paul Treyhearn and Gareth Denier.