 Glioblastoma is a highly aggressive form of brain cancer with a poor prognosis. Recent research suggests that physical forces, such as stretching and compression, play a critical role in its progression. These forces can activate certain proteins, including YAP slash TAZ, which are known to promote tumor growth and invasion. Additionally, these proteins can interact with other signaling pathways, such as AKT, MTOR, and WNT, which are also dysregulated in glioblastoma. Understanding the role of mechanobiology and YAP slash TAZ in glioblastoma progression could lead to the development of novel treatments for this deadly disease. This article was authored by Bruno Pantes and Fabio