 Children with pediatric obstructive sleep apnea can experience negative effects on their neurocognitive function and development, impeding their academic and adaptive goals. Questionnaires are suitable for assessing neuropsychological symptoms in children with sleep-disordered breathing. In this study, we evaluated the effectiveness of using the oxygen desaturation index compared to the obstructive apnea-hyponia index in predicting long-term consequences of sleep-disordered breathing in children. Our results showed that children with an oxygen desaturation index, ODI, greater than one event per hour exhibited symptoms in four domains, physical, school-related, quality of life, QOL, and attention deficit hyperactivity disorder, ADHD, at follow-up, compared to only two symptoms, physical and school-related, found in children with an obstructive apnea, hyponia index greater than one event per hour at the time of diagnosis. Furthermore, our study found a significant correlation between the minimum SPO2 percent recorded at diagnosis and several outcomes, including pediatric sleep questionnaire, PSQ, scores. This article was authored by Marco Zaffanello, Giuliana Ferrante, Leonardo Zacante, and others. We are article.tv, links in the description below.