 This study examined the oxidative stress status of patients with thoracic aortic dissection, TAD, a life-threatening condition caused by aneurysms in the aortic wall. The results showed that the systemic oxidative stress status was increased in patients with TAD compared to healthy controls. Furthermore, the oxidative stress levels were found to be higher in patients who did not develop any complications such as malperfusion syndrome or aneurysm formation. These findings suggest that oxidative stress may play a role in the development of TAD and could potentially serve as a marker for predicting patient outcome.