 A simple approach to 3D print thick, vascularized and perfusable cardiac patches that completely match the immunological, cellular, biochemical and anatomical properties of the patient is reported. The ability to print functional vascularized patches according to the patient's anatomy is demonstrated. Blood vessel architecture is further improved by mathematical modeling of oxygen transfer. This article was authored by Nadav Noor, Asaf Shapira, Groovin Edry, and others.