 This study investigated the potential of sesame gum, SG, extracted from the leaves of sesame radiatum as a matrix former for direct compression tablets. The results showed that SG controlled the release of theophiline similar to hydroxypropyl methylcellulose, HPMC. Therefore, it may be used as an alternative excipient in regions where sesame radiatum can be easily cultivated. This article was authored by Elijah Nepp, Kofia Sorriado, Indidisim Guluca, and others.