 This systematic review aims to summarize digital health competencies investigated among health care professionals, the tools used to assess them, and effective interventions to improve them. The study found that mainly descriptive studies with issues regarding methodology quality have been produced to date, investigating for main categories of digital health competencies mostly with non-validated tools. Competencies investigated might be considered while designing curricula for undergraduate, postgraduate, and continuing education processes, whereas the methodological lacks detected might be addressed with future research. There is a need to expand research on psychological and emotional elements, and the ability to use digital technology to self-learn and teach others. This article was authored by Jessica Lungini, Giacomo Rossettini, and Alviza Poliz.