 B and WASP venoms have been used for centuries as traditional medicines due to their potent anti-inflammatory and antimicrobial effects. Recently, researchers have begun to explore the potential of these venoms as sources of novel therapeutics. Melitin, Apamin, and Mastoparin are three of the most well-studied components of B and WASP venoms and this review summarizes recent advances in our understanding of their structure, function, and potential applications in biomedicine. This article was authored by Miguel Moreno and Ernest Giralt.