 Abstract, CRISPR-Cas9 is a powerful tool used for gene editing and modification. It has been widely adopted in various fields such as agriculture, medicine and biology. Non-viral nanoparticle delivery systems have been developed to deliver CRISPR-Cas9 components into cells or tissues. These systems offer advantages over viral vectors due to their safety, efficiency and ease of use. In this review, we discussed the current status of non-viral nanoparticles for CRISPR-Cas9 delivery, including their advantages and disadvantages. We also highlight some of the challenges faced with these systems and provide potential solutions. Finally, we discussed the future prospects of non-viral nanoparticles for CRISPR-Cas9 delivery. This article was authored by Deepak Kumar Sahel, Lalith Kumar Kevora, Ishwarya Saraswat and others. We are article.tv. Links in the description below.