 Flexible surface-enhanced Raman scattering, S.C.R.S. spectroscopy is a highly sensitive and non-invasive technique for detecting a wide range of molecules, with recent research focusing on its unique advantages compared to rigid substrate-based S.C.R.S. The report highlights the latest advances in flexible S.C.R.S. diagnostic devices, including point-of-care diagnostics, cutting-edge S.C.R.S. techniques, actively tunable S.C.R.S., swab sampling strategy, and in situ S.C.R.S. detection approach. These flexible S.C.R.S. substrates with low-cost, batch fabrication, and easy-to-operate characteristics can be integrated into portable Raman spectroscopes for point-of-care diagnostics, which are conceivable to penetrate global markets and households as next-generation wearable sensors in the near future. This article was authored by Kaichen Tsu, Rui Zhou, Kunihara Takei, and others.