 Poloximers are block copolymers composed of poly, ethylene oxide, PEO, and poly, propylene oxide, PPO. They have amphiphilic characteristics and are used in a variety of applications such as solubilizing compounds, stabilizing drugs, and providing physiologically relevant properties. Additionally, they are used as excipients in pharmaceuticals due to their low toxicity. Challenges faced in nanomedicine include transporting in soluble drugs throughout the body and delivering them to specific locations. Poloximers offer potential solutions to these problems through their rich phase behavior, which includes micelles, hydrogels, liotropic liquid crystals, and more. These properties make them suitable for a wide range of processing techniques, including direct solubilization, solvent displacement, emulsification, and preparation of kinetically frozen particles. Poloximers are thus highly versatile and can be used to create a variety of products, including nano-encapsulated drugs. This article was authored by Andrew M. Badradi and Pascalis Alexandridis.