 We conducted a comprehensive literature review to identify potential prognostic biomarker candidates for hepatocellular carcinoma, HCC. We then validated these candidates in three different datasets, including RNA sequencing, microarrays, and gene chip data. We found that 180 out of 318 genes remained significant in Asian patients after multiple testing correction, while none remained significant in Caucasian patients. However, we did find that stage and expression of certain genes such as CENPH and CDK4 were significantly associated with overall survival. Additionally, we identified KIF18A as the only gene that predicted vascular invasion in both the affometrics and Illumina datasets. This study helps to eliminate biomarkers with limited capability to predict overall survival or vascular invasion, which can be used to further refine prognostic biomarker candidates for HCC. This article was authored by Aetelia Menihart, Adam Nagy, and Bolas Gyrffy. We are article.tv, links in the description below.