 This umbrella review synthesizes the available evidence on mental health outcomes of quarantine, and isolation for preventing infectious diseases, finding severe mental health problems among individuals and populations who have undergone such measures. The study highlights the need for multi-pronged interventions including policy measures to strengthen mental health services globally, and promote psychosocial well-being among high-risk populations. This article was authored by M. D. Mabab Hossein, Abyda Sultana, and Nitu Perot.