 Immunotherapy has become increasingly popular in the past few decades due to its ability to treat various diseases, including cancer, infectious diseases, inflammation, and autoimmunity. Nanomaterials have been used to enhance the effectiveness of immunotherapies by improving the stimulation of immune cells, targeting specific areas of the body, and reducing side effects. Recent studies have shown promising results in treating these diseases with nanomaterial-based immunotherapies. This article was authored by Sean Ruffin, Wei Guisou, Joan Meenley, and others.