 The literature review aims to identify gene polymorphisms associated with chronic periodontitis, CP, susceptibility, focusing on Illinois 1, Illinois 6, Illinois 10, vitamin D receptor and CD14 genes, but the evidence is limited by varying carriage rates of rare alleles among studies and underpowered designs. A more comprehensive insight into gene polymorphisms contribution to CP requires larger cohorts, well-defined phenotypes, control for other risk factors, and analysis of multiple genes and polymorphisms within the same pathway. This article was offered by Marger L. Lane, Bruno G. Luz, and W. Krylad.