 I'm giving the closing talk of this, and I wish I'd been here for more of the two weeks, but I'm going to start with something that somebody said to me, they were part of I think the 35th of these, it's 60 today, she said it changed her life. By giving here for two weeks, in the 35th it changed her career, it changed how she saw the world, she met people that she's still friends with. What could be better than that? Today I'm going to talk about what I've done in my own career. I'm going to talk about the challenges politically that we're going through at the moment, and how we can't accept some of those. And I'm going to choose something which is close to my heart, which is around emerging infections and the challenge the world faces, but really just as an example of how unless we come together as a world and address common challenges, we won't be able to address any of the great challenges of the 21st century. Climate change, emerging infections, inequality around the world, and I think by bringing everyone together in one place for two weeks, that's the sort of thing that changes the world.