 Welcome ladies and gentlemen and a healthy good morning from the annual meeting of new champions 2015 in Dalian China and Thank you for joining us here in the room and on the live stream and on YouTube You're joining the briefing session on the latest breakthrough innovation in health and The the British singer Adele. She sings in one of her songs We could have had it all and I have to say We are very close to that having it all because we have a wonderful panel today from our technology pioneers community And the people joining and joining us here today. They're entrepreneurs their researchers their innovators and their health experts So we're very close to having it all and allow me the note We also have a very nice gender balance on the panel, which is something we sometimes struggling with so I'm so I'm very happy To present that panel to you Right to my immediate left is fully Montrezeur. She is the head of the technology pioneers community at the World Economic Forum Next to her is Ron Goodman. Who's the founder and chief executive officer of health tap? Further down the line. We're joined by Katherine Boffley who is the chief executive officer of editors medicine and Last but definitely not least. We're joined today by Nina Tandon. Who's the president and chief executive officer of EpiBone? and without further ado full via let me hand over to you and Why don't you give our audience a bit of background? Who are the technology pioneers and? What role are they playing here at the annual meeting of new champions? Thank you sure So technology pioneers are a community of the form that are made up of early stage companies That are all involved in designing developing and deploying new cutting edge technologies And we expect them all to have a very big impact on society and industry So just as sort of an example, you know past tech pioneers have included companies like bloom energy bluebird bio Google Twitter and nest so some household names And they really come from all sectors so everything from alternative energy sources to artificial intelligence robotics Digital security I could go on and on In terms of their role at the annual meeting of new champions it's really being able to help provide all of those insights on which technologies are going to change our industries change our society and to Use the opportunity of having public and private cooperation here to help grapple With all of the challenges of bringing these society these technologies to market Thank you Now we obviously want to hear more more about you and and Catherine I start with you because I know you received the large investment recently congratulations for that So let's say you're meeting an investor in two to three minutes. What's your elevator pitch? How what are you telling him? What are you doing? And what is the impact of what will the impact of your company be? Well, the most fundamental idea is what if you could repair broken genes? edit test medicine is a biotechnology company that focuses on genome editing and The technology the name of the technology some of you may have read about called CRISPR-Cas9, which is a Very jargony description as often scientific names are But the fundamental idea is what if you could repair broken genes? We've known for a long time that a mutation in a gene or a mistake in the DNA can lead to a disease Those are often some of the most difficult diseases to create medicines for diseases like cystic fibrosis or Huntington's disease ALS amyotrophic lateral sclerosis and the list goes on. There are over five thousand Genetically driven diseases and then also beyond those diseases We know that genetics do play a very significant role in many other diseases And so we've known for a long time if we could repair the gene at the level of the DNA That would be a very compelling way to potentially address those kinds of genetically driven diseases But we haven't had good tools to do that and that's where this genome editing technology comes in is a precise and Specific way to be able to correct the DNA at the level of the gene Still a lot of technical challenges to really turn that into medicines But this this young but very exciting and powerful science that's come out of academia in these past few years Has we begun to translate that that's what we're doing at Editas is to translate that into medicines for a wide variety of these diseases Thank you very much Nina over to you. What's what's your alibis, which how are you telling people about your company? What are you doing and what's the impact? Yeah, well many people don't realize that after blood bone is the most transplanted human tissue and quite literally the only way even now to get human bone is to cut it out of a human and Needless to say this is there's no piece of bone. That's not necessary and And so what we propose to do is actually something a little bit different is to is to take the cells that grow our Bones in our bodies every day and to utilize those in the laboratory to grow new bones that can then be used to repair the body Thank you run What what does your company do and what's the impact? How do you how do you explain to people what you're doing? Absolutely, so, you know, it's all about world-class healthcare democratized now We're basically building a global health practice A place where you can actually access some of the best physicians in the world Anytime anywhere from any mobile device or web connection We have more than 72,000 physicians in our network. You can access them by text by video or by voice 24-7 these are some of the best physicians in the world. You can ask him any health question You can get answers in minutes or in seconds You can actually get tips from them about how to manage your health and well-being You can read what news they recommend what health news they think are medically sound You can see reviews that they provide on medical apps and also even on medications So they share their opinions and actually we serve more than 3.5 billion Doctor answers and tips to date to people all over the world We're growing in the US, but we're also growing very rapidly internationally right now And we provide our services either direct to consumers so you can just download our app or health app app on Apple or Android phones Or you can go online to healthapp.com and just go and access all this wealth of medical information for free in minutes And the immediacy of the information that makes us unique. There are no delays. There are no waiting rows You can actually either engage with this content for free and just learn about your health and even ask these Doctors questions about yourself and get answers in minutes or you can subscribe to our premium services and pay a subscription fee and Then get immediate access on a non-going basis to these doctors from any mobile device or web connection You can either buy it yourself or have your insurance company or your employer buy it for you because we're working with enterprise now and As of recently we actually started working also with hospital systems And we provide our platform as a service to hospitals all over the world to provide virtual care to their own patients With their own doctors, so it's either provided by our network of seventy two thousand US licensed physicians Or by the doctors of the hospitals that license our software Thank you Ron, and I have to say I'm very happy that I'm not competing for funding with the three of you Very impressive full view back to you. Let's pretend. It's just the two of us in the room and nobody's watching Why did you choose these three companies for your for your community? Let me put you on the spot? I Think all three of them are just doing such unique unique amazing things but the Scope of impact of each of them as they've described in their own words much more effectively than I can is going to be huge It really is going to Change the way that we deal with diseases that we deal with daily health care that we deal with you know Accidents and requirements for new bones So all of these are really meet our requirements of technology pioneers true amazing innovations that will have huge impact Thank you. Thank you We've been discussing earlier today about the the challenges that that the three companies are facing so What do you what you share with us and Nina? I'll start with you this time What what is the biggest challenge you're facing and keep in mind the forum is a multi-stakeholder organization So you have all these CEOs and regulators here. So make this your wish list. Hey, what's the challenge? And what would you tell the people here and say come on you can do that for me to help me, right? So so we're EpiBone is actually based in the United States. So I don't I can't comment. Well, my comments are mostly About the US although I think that It really does encapsulate kind of the world view from a regulatory perspective on Cell therapies so so essentially with EpiBone we have a therapy that's Where some of the material that goes into the therapy is derived from the patient themselves And so this this represents a shift in how medicine has been developed and then therefore how it it implies that There are going to be changes with how that kind of therapy will go through clinical trials The idea of a double-blinded study is impossible to do if you have a person who's providing the ingredients for a therapy In addition there, it's very difficult to to think of what a healthy control is You know, there's no analog in the cell therapy world for take an aspirin if you don't have a headache And so when we think about where we are now we're testing in large animals We've implanted 30 pigs to date with new bones in there in their face And we've seen really good results and we're thinking how do we how do we map the results? We've seen towards clinical trials and this does present a challenge the good news is is that? that the regulators or scientists themselves and have been very gracious with us in terms of You know having a dialogue in fact they reached out to us at conferences to to try and help us think about clinical trials But there are there are many challenges Think map, you know concepts that sound very simple things like dose Very hard to define when you say okay Well cell therapy what does a dose mean and and maybe it could mean the number of cells that are infused in a bone Before engineering it maybe it could be the amount of time that we mature the bone before it gets implanted into a person How do you map concepts like pharmacokinetics to to a therapy that remains in the body? So there are many challenges that abound But the good news is is that we're in the United States, which is a place that is a large market In fact, it is the largest single market and and as it seems to be that the mood Is is one of collaboration? So this is very heartening to us. Nonetheless, you know, we're scientists and we're we're not We're not business people. We're training ourselves as we go along and and gathering the help of experts But we are worried, you know, are we going to make a mistake at this early stage, you know If as we're moving to meet serum-free media, right? We're moving to serum-free media as we're growing Bones the serum-free media that we're using we're trying to make sure that we're using the same exact ingredients that we will use In people okay, this is for very good reasons, but has after effects like oh Maybe that cell-free media that that serum-free media is not optimized for pig cells Maybe it's optimized for human cells. And so are we going to sabotage our results because we're for example, you know Trying to mimic our process as best we can for very good regulatory reasons, but having a nice side dish of difficulty with Extrapolating the results. So this is just a sampling of some of the of the issues that I think come up with cell therapies But I really think the good news is is that everyone's excited about the potential of regenerative medicine Everyone understands the impact that haven't you know with fewer surrogate revision surgeries that are necessary having implants that last as long as we Do and so I think that the mood is one of collaboration to try and tackle these issues together But that's just a sampling of what we're what we're up against at the moment. Thank you Catherine What do you want to add? What's your perspective on this? Well, it's interesting because hearing Nina talk about her challenges I'm nodding and I'm thinking yes I know exactly what you're talking about and I realized for a lot of folks who aren't in that deep detail of developing new medicines Some of the challenges seem a bit arcane very technical But how do you test appropriately? With scientific rigor with taking into account all the appropriate ethical considerations when you're doing something as a Potentially permanent change like the kind of bone approach you're taking or what we're doing in terms of editing genes You do have to test these to make sure they actually are working appropriately and are they safe enough? But the the ways that we test other medicines We can learn some lessons, but we're gonna have to really invent new ways to appropriately test those And I think you may mention the regulatory authorities the FDA the EMA the authorities in all the different countries where you want to We'll be taking that journey with us I think they tend to be quite science-driven, which is which is what we all want as consumers as well and we will all be working to find the right way to Test these new medicines and these new therapeutic approaches to figure out if they are doing what we Hypothesize and hope that they will do Beyond that all the normal challenges of building a company Finding the right people finding the right capital figuring out your plan we can go on and on forever But this is where I suspect that you have a lot of familiar challenges as well along these lines Yeah, I mean, you know after Hiring 72,000 physicians into our network. I can say that you know bringing physicians on board to engage And to do things with us, you know initially for nothing, but they still help to serve more than 3.5 billion doctor answers Bringing the best and top talent is very important right and in medicine and in engineering Which are the two areas where we spend most of our time in these are some of the most challenging hires to make And I think that we focus on top top talent only because people when they access medicine or when they build technology They need to be the best in the world in order to tackle some of the most important Challenges that we have so finding the most amazing people creating Access to top quality healthcare everywhere Spreading the knowledge right making it available everywhere in every language, right? So, you know, we created this amazing repository You know that with over more than five years with the second to none and scope in depth that created by some of the best doctors in the world How do we Translate it to every single language because we are going to create access to medical information and democratize it in ways That were just impossible and be accessible from any mobile device or web connection to people who don't have access to health care and doing that is very important But we need to harness and bring with us together and inspire Doctors from all over the world because we want to make sure that the quality of the content remains Awesome, right? So that's an important thing for us and as we're moving from a more market-based Economy in health care in the United States into a lot of government-based health care throughout the world We need to also start talking with government constituencies and explaining to them Why we are providing higher quality health care faster access at the lower cost, which is basically singing their song I mean, this is what governments are looking for actually and building it with technology and with engagement that enables the government To actually provide better care at a lower cost And I think that working with these constituencies and empowering them to provide health care to to their people Right in a better and easier way on their terms actually, right rather than saying, oh, no We're gonna do it our way We're gonna say let's do it collaboratively right figure out what the challenges are How can we use our technology and our know-how to help you provide better care in a lower cost is the most important thing That we're doing now all over the world. Thank you to my next question, which is you you've all touched on the Working through and they range from your technology to regulatory to society also getting the doctors on board people capital Where do you see the role of meetings like this where you really have a Both private corporations as well as Public leaders coming together and convening in helping overcome those challenges and I'll start with you since you were already going that down that path That's fantastic. I mean like it's it's really amazing I mean for me it's just an unbelievable opportunity to meet people from government from industry That are really thinking about the bettering of the world right so the common denominator here for us Is really second tonight right like meeting these people that are minded to helping their Constituencies coming together solving problems having these awesome discussions both in the sessions, but also in the corridors, right? So I've had amazing discussions here with people just learning what what is important for them What are their challenges? How they're looking at healthcare from different perspective from different cultures, right? And having a real conversation For us as a company's amazing wonderful and Katrina I'd love to hear from you How what you sort of hope to achieve those the next few days and how this helps? The area of genome editing is perhaps a bit unusual in that even though it is a young field it has very much Both burst on the scene in a much broader way than just new medicines I mean it was on the cover of the Economist last week and and has really become not just a Topic in the scientific community or the medical community, but much more broadly because of the ethical implications and also because you know the idea that you could do something that's long been imagined and now is Possible it is a it is a spectacularly quick change And so I think a lot of us are grappling with it and I live this every day But absolutely recognize this is something that has much broader implications than just the specific medicines that we are working on So meeting like this is a wonderful community to to talk to people who want to engage in very complex multi-dimensional important Challenges that have great potential, but may maybe bring a lot of questions along with those challenges You know we all want to who doesn't want to help fix genetic diseases But the technology is not limited to that in how it might be used And so we have to engage a much more greater cross-section of community Regulators and all of that but also you know people in ethical bioethicists and people who think about this at a broader economic level All being part of the conversation. This is a wonderful place to engage in a very multi-dimensional way Yeah, I just want to second what everyone's saying You know it's a forum like this brings together from the health care ecosystem all of the relevant stakeholders in a way That's that's very powerful. I mean everyone from the regulators to the patent lawyers and government payers and people in the field of biotech So when you think about a new a patient-centered Paradigm of medicine that everyone seems to want and and is such a global challenge You know every every individual country is struggling in their own way to actually have people in the same room who can compare notes and learn best practices and You know in the corridors as well as in the in the public forums, I think it's very powerful I think what's also interesting for me is that you know You know just a second what you were saying about how we're really at this moment where we're starting to to see science fiction become science reality and the The sort of Gutenberg moment that we find ourselves at right now where we can you know read and write in ways that we never could Imagine before to the human genome is is so powerful and you know we see ourselves as part of that story You know if you guys If the if we're at this movable type, you know if you guys are if that's what CRISPR is You know, maybe we in regenerative medicine or the ink because we're actually being able to grow the At a different scale, you know, we were able to control Biology in ways. We've never imagined what we've imagined but never been able to do before every relevant scale from the genome to the To the cellular level and then now to the three-dimensional level and I think what's very interesting about this is that sure We're exploring new ideas about the boundaries of the body and the potential for medicine and human health But this has applications in industry way beyond health, you know, if you can think about People that are doing, you know in different corners of the world really interesting work with with this paradigm of what can we do if We collaborate with biology and we we think of this of the cell as a factory With programming that can be edited not just to the human genome, but with bacteria What can we do? We can start to think about tackling issues and sustainability if we think about, you know, there's a Really great bio mineralogist based in Singapore who's collaborating with bacteria to to mine valuable minerals from Desalination brine which is a toxic byproduct of the desalination process, you know You can start to do that creating wealth from waste by collaborating with biology And so what I would say is that at a meeting like this We can finally have discussions about how do we tackle issues of sustainability by by by beginning to collaborate with biology You know after as we're starting to come up against the limits of what we're able to do with traditional physics and chemistry I think that's a very powerful conversation and it's one. That's where that's much beyond even the amazing boundaries that that health provides Just one add what one more small thing that was really amazing for me If we're talking about discussion and thinking and talking But I would talk also on the pragmatic dimension of the forum I think that you know, you're bringing together Both innovators, you know young innovators on the one end that are very excited doing new things changing things In a very significant way, but also the implementers the people that are they in and they out managing large populations And they're creating what taking these ideas and they need innovators They are slow to innovate They're slow to think about the future but they deal with everyday issues all the time and they need innovation in order to Do things better and faster and the innovators need the access to the people that actually have the populations And the fact that you're bringing both of them together Not only for a discussion and I can tell you from my experience helped I've got a lot of opportunities here to really talk with some of these amazing partners to take some of our Innovation and bring it to actual markets today and that's amazing So that's not just a conference to talk about things but actually to get things done Thank you, and I like that there's this pragmatic aspect of what can we implement right now? And I really second your your emotion of this being science fiction So could you help us all crystal ball, and I know it's very difficult to do but ten years into the future What does health care from your lens look like? Not me Whoever would like to start let me channel my my crystal ball Let's see. I think quite clearly we're going to be Well in ten years ten years is actually quite a short a short period of time in our field I I hate to say it, you know if you're you have to be a marathon runner Who sprints every day for decades, right? So but let's just you know put that aside and think well, I think we're going to see Remarkable changes probably most immediately in oncology. I think this is a disease where The genetics really have a big impact the understanding of cancer as a genetic disease is Is put is being put into practice and I I think that's where we're going to see the needle move most quickly because the stakes are So high and the genetics are something that we can begin to understand Much more quickly. I think we're also going to start to see more regenerative therapies like what we're working on You know, it's been a long road for us. You know the first therapies were first Approved in the 90s and many people say hey many people assume that our technology is one that they can just get at the doctor already And so I hope that this kind of There's going to be a bit of merging between Science fiction and science reality. I think we're going to start to have more living therapies on the market whether it's You know, whether it's yogurt that can help us detect colon cancer like sanghita Bhatia is working on Amazing work, right? Or if it's going to be things like what we're doing I hope that will be approved by 10 years from now and that congenital defects and Bone resections will be something solvable. We won't have to treat the human body We won't have to Pretend that we won't have to interact with it as if we're carpenters essentially We're going to be able to extend our healthy lives And one thing that I really love about our work in skeletal reconstruction is I think that it has this after effect of Maintain this a beautiful after effect of maintaining our bodies and allowing ourselves to really Remain active is that we can maintain the health of our minds Which is still I think going to remain a mystery even even 10 years from now I get really excited. I think we're going to start to see More merging of scientific disciplines if I'm going to look into my crystal ball I I see I see the cosmos, you know, I see the physics of the Of the universe that the things like quantum physics things like astrophysics I think we're going to start to understand more and more how those mechanisms are resident in our own bodies in things like DNA mutation and many other things I could go on and on but I think we're going to start to see a merging of disciplines a lot of New fields that will have strange sounding hyphenated names and and lots of exciting new ways to to maintain our health Ron, can I get you to crystal ball? Yeah, I'll try to go and find myself the three things that I think That are very exciting for me right part of a lot of very very exciting evolution in healthcare and poetry Alongside that I think it's really really inspiring for us to see some some of the amazing amazing thing that are happening in science That will build into what we're doing when we provide health care, you know on the ground I think that we're moving from delayed health care to immediate health care from a world in which we are used to waiting in waiting rooms For doctors and waiting for days and sometimes weeks to get into specialists and surgeries to a world in which we get immediate care From any time anywhere, right? So we push a button we get in front of a doctor we push a button We get in front of the knowledge immediately we want to get a test done We want to understand our data it happens in seconds right rather than days or weeks or month the second thing that I want to say that we're moving from Reactive to proactive medicine and that's really exciting as we're starting to quantify and measure everything and the data stream We're starting to come together and go into the doctors go into the people that have the knowledge Putting this data together when it's streamlined will allow us to see variability At a time before we actually understand what what's wrong with us So today we go to a doctor we seek care when something's wrong We're feeling a pain at this comfort and now it's time to go to the doctor to a hospital or something is bleeding in the future The machine will see that something is about to go wrong with us because the signs Existing us before we actually feel the pain before we feel the discomfort and once all this data is aggregated into a place That they can then interpreted by doctors say all this sign that is irregular is actually something to worry about Then we will be able to basically send a signal back to the person and say hey You should avoid this you should not do that Well before you get the heart attack or the stroke or the thing that will actually cause you asthma attack or things That are not as bad as you know a heart attack So reactive to proactive and the second thing from local to global I think that knowledge exists. It's just not in the same geography It's just not at the same time and our ability to access the best knowledge that exists somewhere in the world and Equalize the ground democratize access to top quality health will be available to all so between delayed to immediate Reactive to proactive and local to global will see a different health care and better health care to everyone Thank you and could train if you could Go lucky last sure So I do live most of my most of my world in the very focused world of creating new medicines And so it's it's fascinating to hear you guys talk about all these grant connections and and you know I really live in the world of making new medicines I think that the The point that I would focus on the most is Genomic medicine becoming a reality in this time scale is need to mention ten years in the world of making new medicines. I Hope to have one product on the market in that time frame Let's be realistic that would be a fast wonderful accomplishment to not only translate this new science that we're working on But to turn it into an actual medicine that is available to actual patients My aspiration is to do a lot more than that But if I look at how difficult it is to make new medicines that I want at least to be able to do that And I know that all the scientists back at at a toss and the others in the industry and in this field think the same way But I think that the the bigger Canvas in which this is happening is Genomic medicine becoming a reality, you know as a society Over 15 years ago. We made the investment in the human genome project And I think a lot of folks may say well what came of that It it underlies everything we do now because we can Look at a genome rapidly Cheaply and accurately, you know costs whatever billion and more dollars to do the first genome and now costs less than a thousand dollars And it's faster and it's more accurate than the first one. What does that mean? It means that physicians Can now begin to think differently about how that information Informs their understanding of a patient's health Understanding of how their genetics might inform their health status genetics isn't everything It's one really important factor It's not the only fact that drives your health, but being able to have that incorporated as a one of the starting points The genetic information being one of the starting points for a physician I think will really shift how medicine is practiced and you do see this you mentioned in cancer Yeah, they're television advertisements in the US about cancer treatment centers who who say we sequence your genome as Our starting point of that's consumer directed advertising already talking about genetics driving therapeutic choice Cancer is probably the forefront front of that connection, but you do see it starting to impact All the other therapeutic areas and I think if you have medical students starting to think that way the next generation of physicians Are going to approach their concept of disease differently than prior generations Thank you very much You spoke about immediate medicine We have a bit of a waiting room here as well because we're running over time, but Before I can I open the floor for questions We ask we ask our audience on social media for questions and and we always have quite a young audience on the live stream Especially and and somebody wrote to us Chinese Chinese young man wrote us and said look I checked out the websites of the three companies and I'm fascinated now Tell me what should I learn? What are the skills? I need to work of one of these companies and what should I study because it's so much more than than the medicine So maybe you can give us like your one sentence answer of what should a person study to be hired by you From my perspective be study what you're passionate about I mean the number of different technical disciplines required to ultimately bring a new medicine to Approval it's it's legion. It's everything from biochemistry to molecular biology to cellular biology to material science to Clinicians to people who come from the regulatory perspective. I mean I can make a very long list And if you study what you're passionate about there are many many different ways that you could become part of a company like This what I do know is everybody that I work with and the number one reason that on there is People that are there are fantastic and being able to work on this mission with them is the only way you can face these really really really hard challenges Yeah, I would I would second that I would say, you know look within and and see what you're most passionate about and and if and Triangulate between that passion and the mission of the company and they're There are so many ways to interact with this technology You know that said I think another thing that's oftentimes people aren't aware of is that the barriers to learning about Cells and genetics is coming down so much especially in the United States. There's a movement of Citizen scientists, you know, essentially, you know hundreds of years ago You didn't have to go get a PhD before you were allowed to experiment, you know you had Galvani on his rooftop with frog legs, you know studying lightning, right and and and at some point You know as we as the knowledge that we've gleaned has become more and more complex We've created disciplines and and people have become in some ways disconnected from each other And and one thing that I find very interesting is that there are new ways for people with no training to be able to Contribute to cancer research for example, there's a website called Zuni verse where you can log on and Help analyze images real images from real scientists and and help them look for help with cancer detection There are games that you can play online like folded that can help you contribute to science without any training and there are Community-based bio labs that are popping up all over the world where anyone from artists and architects can learn the techniques of Genetic engineering for the purposes of Exploration, you know learning scientific methods without being beholden to the scientific process of generating Hypotheses and testing them and so we're starting to see a beautiful proliferation of work From bio artists and and architects and all kinds of people who you wouldn't think would be Necessarily experimenting with biology and so I would say you know There are so many ways to connect with the interesting work. That's happening in the world right now and You know just just find find whatever meets your passion and go with that So it's a combination of two things One of them is another second and third what you guys just said now You know healthcare is a very mission-based practice, right? So learning the human condition and falling in love with helping people is Fundamental to everything right so we we hire people at health time It doesn't matter how skilled and smart they are if they're not mission-driven we don't hire them, right? So we want the intersection between smart capabilities and being mission-driven and wanting to help people Right so learning the human condition understanding what's going on around the world especially for people that are more privileged To understand what people really need you know all over the world and how we can help them is the foundation When you have that I think that the second thing that is extremely important I would recommend especially the people that are building their careers right now to go and do a lot of math Right, so yes Data statistics engineering are all the future. We're going to see a lot of data coming together from a lot of sources Data is the new oil right? It's a lot of opportunities in the analyzing data Understanding data improving people's lives using data from going from reactive medicine to proactive medicine To genomics to other areas if you have deep knowledge of data and math and you know how to analyze it You're going to create magic in the future So investing in math investing in data investing in knowledge of analyzing and working with data is very very important And we'll create a skill for you to participate either in really work in data directly or just in engineering disciplines That require the same infrastructure. I would highly recommend that. Thank you very much Alright, can I see a show of hands on the floor if there are any questions? We have a microphone If not and mindful of the of the full schedule of everybody. Well, thank you full via for bringing this wonderful representatives of the technology pioneers Here to the panel and thank you all panelists do as the Chinese student has done go to the website of editors medicine of EpiBone and of health tap find more information about the companies and You can rewatch this press conference on our website and soon in YouTube So and and shared of course our hashtag is hashtag AM and C15. Thank you for joining us. Thank you very much Thank you