 लोड हम स्व ची दी धी आप थीवीच टीवीचvana law मैं भाछ दोध तीवीच paj b by lund etus  promoters this is yu can say that the blade so when there is a cells either the bubbles when these cells collide with this impeller then they rupture. In case when there is radial flow impellers, then the burst of the cells happened but on case of when it collide with the air bubbles that having the reduction of the air bubble size that is the positive point in radial impellers. But sometimes when we need the shear effect towards the cells but sometimes it goes negative when we talk about that there is a continuous shear to the cells there is no because there is no mass culture and all the time when there is a disruption of the cells then there is the increase of the toxicity inside the fermentor. So that is why sometime that that is very negative impact of the choice of radial impellers. So that is why we see that as concerned of the high shear that is effective in breaking of the bubbles for this reason the radial flow impellers are used for the culture of highly aerobic fermentation process. Because when there is a need of the highly aerobic process means the metabolic requirement of the organism need high oxygen high concentration of the oxygen that can only be supplied when there is a more solubility of the oxygen inside the fermentation medium or among the medium of that. Because when we have to supply the air into the medium so the gases phase first go have to into the liquid phase. So first the gas oxygen has to dissolve into the medium so the number of factors effect on the solubility of the medium. We will talk about this particular mechanism of solubility while we will talking about the chapter of aeration and agitation and the requirement of the oxygen said how much amount of the oxygen is required that as we know that the metabolic equation that one mole of glucose require six mole of oxygen to have a complete respiration. So as when we use the simple the common air and we know that if the air is having a good quality that mostly have 21% of the oxygen in the air. So when we supply the air that air bubble size as much as the size of the bubble will reduce then there will be a more surface area. When there will be a more surface area then there is a more chance of oxygen solubility in the medium. So there is a very positive that is why the positive factor by selecting the radial flow impellers. But on other hand I have already told you that high shear can also damage the shear sensitive material such as the crystals and the precipitate and shear sensitive cells such as filamentous fungi and animal cells. So very critical by using the radium impellers. When we talk about the radium impellers so that is a fact that how you design and what is the shape of the blade of the fermenter.