 Biosynthetically produced nanoparticles, N-piece, are gaining increasing attention due to their potential use in pharmaceutical applications. These N-piece can be derived from natural sources such as plants, animals, and microorganisms, and they offer advantages over synthesized N-piece, including increased biocompatibility, improved stability, and decreased toxicity. Additionally, these N-piece can be used as drug carriers or as therapeutic agents themselves. This review discusses the different types of biologically-derived N-piece, their applications in pharmaceutics, and their potential for use in biogenic nanomedicine. This article was authored by Maria P. Nicolova, Pyle B. Joshi, and Murphy S. Saweri.