 This research aims to understand the differences in major land cover change results caused by various time periods and examines the impacts of human-induced factors on land cover changes along the Trans-Amazon highway region using Landsat thematic mapper and operational land imager data from 2011, 2014, and 2017. A classification system consisting of five land cover classes was used, and a hierarchical-based classification method was employed to generate land cover classification results. The emphasis was on deforestation, dynamic change between secondary forest and agropasture, and urbanization over time. The study found that selection of a suitable time period is critical for accurately detecting land cover changes, and human-induced factors play important roles in deforestation, dynamic changes between APMSF and urbanization.