 Kirkum along the rhizome extract, CLE, showed weak inhibitory activity against mushroom tyrosinase compared to kojic acid, but both compounds exhibited moderate toxicity to be 16F10 cells. Further research is required to determine whether CLE can be used as a potential ingredient in skin-lightening products. This article was authored by Denny Formancia, Sri Adi Sumiwi, Nye Mekkar Saptarini, and others.