 Over the past 10 years, there has been a significant increase in interest for intranasal drug delivery as a non-invasive method for administering various therapeutic compounds to target issues in the nose, system and central nervous system. The paper reviews the anatomy, physiology and histology of the nasal region and discusses the biological, physical chemical and pharmaceutical factors that must be considered during the development of nasal drugs and their incorporation into appropriate formulations. This article was authored by Anaisapires, Ana Fortuna, Gilberto Alves and others.