 1. Isolation due to the management of infectious diseases is thought to affect mental health, but the effects are still unknown. 2. We examined the prevalence of anxiety symptoms and anger in persons isolated during the Middle East Respiratory Syndrome, MERS, epidemic both at isolation period and at 4-6 months after release from isolation. 3. We also determined risk factors associated with these symptoms at 4-6 months. 4. Of 14,992 individuals isolated for 2 weeks due to having contact with MERS patients in 2015, when MERS was introduced to Korea, 1,692 individuals were included in this study. 5. Anxiety symptoms were evaluated with the Generalized Anxiety Disorder 7-Item Scale and Anger was assessed with the State Trade Anger Expression Inventory at 4-6 months after release from isolation for MERS. 6. Of 1,692 who came in contact with MERS patients, 1,656 were not diagnosed with MERS. 7. Among 1,656 anxiety symptoms showed 7.6%, 95% confidence interval, CI, 6.3-8.9% and feelings of anger were present in 16.6%, 95% CI, 14.8-18.4% during the isolation period. 8. At 4-6 months after release from isolation, anxiety symptoms were observed in 3%, 95% CI, 2.2-3.9%. Feelings of anger were present in 6.4%, 95% CI, 5.2-7.6%. 9. Risk factors for experiencing anxiety symptoms and anger at 4-6 months after release included symptoms related to MERS during isolation, inadequate supplies, food, clothes, accommodation, social networking activities, email, text, internet, history of psychiatric illnesses, and financial loss. 10. Conclusions suggest that mental health problems at 4-6 months after release from isolation might be prevented by providing mental health support to individuals with vulnerable mental health, and providing accurate information as well as appropriate supplies, including food, clothes, and accommodation. This article was authored by Hyun Suk Jong, Hyeon Wooyim, Young Joon Song, and others. We are article.tv, links in the description below.