 This study investigated the effects of oxidative stress on exhaled volatile organic compound, VOC, levels in lung cells and in patients with increased pulmonary oxidative stress. Despite a comprehensive translational approach, no consistent associations between vox and pulmonary oxidative stress could be found. This suggests that further research is needed to validate the use of exhaled vox as biomarkers for pulmonary oxidative stress. This article was authored by Dominic Fenn, Tejas Elylion, Laura A. Hagans, and others.