 The patient had a Pseudomonas aeruginosa multidrag-resistant prosthetic vascular graft infection, which was treated with a cocktail of phages, PT07-14-01, and PNM, in combination with septasidim abobactum, CZA. The patient experienced a new Pseudomonas aeruginosa bloodstream infection, BSI, with aseptic residual limb metastasis after the application of the phage treatment and an absence of antimicrobial therapy. Genomic analysis revealed that the clinical strains of P aeruginosa before and after phage therapy shared a clonal relationship but with significant genomic changes that may have contributed to the resistance to the therapy. Phenotypic studies also indicated decreased mics to SS lactams and quinolones, increased biofilm production, and the emergence of phage-resistant mutants in the clinical isolated P aeruginosa post-phage therapy. This article was authored by Lucia Blasco, Lucia Blasco, Imaculata Lopez Hernandez, and others. We are article.tv, links in the description below.