 Simifugian, a component of the root of Sipashikovia divericata, has been shown to have an analgesic effect when administered intrathecally. It was found to reduce the flinch response in both phases of the formalin test, indicating its potential use as an analgesic agent. At lower dosages, it demonstrated an anti-inflammatory effect, while at higher dosages it exhibited a non-inflammatory analgesic effect. This article was authored by Hyeon Young Lee, Young Joon Ki, Soo Young Park, and others.