 Mucodes of drug delivery systems interact with the mucous layer covering the mucosal epithelial surface and news and molecules and increase the residence time of the dosage form at the site of absorption. The drugs which have local action or dose which have maximum absorption in gastrointestinal tract get require increased duration of stay in get. Thus, mucodes of dosage forms are advantageous in increasing the drug plasma concentrations and also therapeutic activity. In this regard, this review covers the areas of mechanisms and theories of mucohadhin, factors influencing the mucohesive devices and also various mucohesive dosage forms. This article was authored by Bindu M. Boddupalli, Julkar N. K. Mohammad, Ravinder A. Nath and others.