 The Clinical and Translational Science Awards, CTSA, program of the National Center for Advancing Translational Sciences, NCATS, has been successful in supporting early-career investigators and innovative early-stage research projects across the translational research spectrum. The Georgia CTSA has funded 183 pilot projects since 2007, which have resulted in positive outcomes in five key areas, knowledge, research targeting, capacity building, policy and product development, and health benefits. These results can be used as a framework for evaluating the long-term outcomes of other CTSAs. This article was authored by Latrice Rollins, Nicole Luellin, Manzingaiza, and others.