 Maranche is a serious side effect associated with certain drugs used to treat bone diseases such as osteoporosis and cancer. It can be treated with conservative methods like pharmacologic, laser, and minimally invasive surgery, but surgical intervention is often necessary for more advanced cases. Surgical techniques such as fluorescence-guided surgery, platelet rich plasma, PRP, platelet rich fibrin, PRF, chondrogenic growth factor, CGF, piezo-surgery, vascular endothelial growth factor, VEGF, hyaluronic acid, and ozone therapy have shown promise in treating Maranche. This article was authored by Angelo Michel and Chingdalo, Giusepina Malkangi, Irene Ferrara, and others.