 Lipid-based drug delivery systems, LBDDS, are a promising technology for improving the solubility and bioavailability of poorly water-soluble drugs. These systems involve encapsulating or solubilizing the drug in lipid excipients, which leads to increased solubility and absorption, resulting in improved bioavailability. Recent advancements in LBDDS have enabled the successful commercialization of lipid-based formulations for oral delivery. This review summarizes the physical-chemical and biopharmaceutical characteristics of lipid-based formulations, as well as the processing techniques used to produce solid lipid-based formulations for oral delivery. Additionally, this review discusses lipid excipients and their characterization. This article was authored by Sandit Kallipur, Mohan Varma Manthina, and Virabhadraswamy Patavala.