 Archeosomes are liposomes derived from archaea that exhibit high pH and thermal stability and can induce strong immune responses in mice. The new class of adjuvants developed by the authors, comprising a sulfated saccharide group covalently linked to an archaeal core lipid, sulfated S-lactosalarchyl SLA, mixed with uncharged glycolipid, lactosalarchyl LA, can be easily synthesized and retain strong immunostimulatory activity. The authors demonstrate the safety of SLA-LA archaeosomes following intramuscular injection to mice and evaluate their immunogenicity in vivo distribution and cellular uptake of antigen, ovalbumin, encapsulated into them. They find that semisynthetic sulfated glycolipid archaeosomes are a safe and effective novel class of adjuvants capable of inducing strong antigen-specific immune responses in mice and protection against subsequent B-16 melanoma tumor challenge, with the recruitment of immune cells to the injection site and subsequent trafficking of antigen to local draining lymph nodes being a key step in their mechanism of action. This article was authored by Bassler Catch, Felicity C. Stark, Umar Iqbal, and others. We are article.tv, links in the description below.