 This study examined how mesenchymal stem cell, MSC, derived exosomes can be used to reduce inflammation caused by burns. The researchers found that burns increased the production of pro-inflammatory cytokines such as TN-Phalpha and IL-1-beta while reducing anti-inflammatory cytokine IL-10. They also discovered that these effects are mediated by microRNA, MyRNA-181C, which is present in MSC-derived exosomes. When administered to burn victims, MyRNA-181C-containing exosomes were able to reduce inflammation by down-regulating the toll-like receptor for TLR4 signaling pathway. This suggests that MSC-derived exosomes may be a promising therapeutic option for treating burn injuries. This article was authored by Xiaoli, Lingying Lu, Jingyang, and others.