 Cancer is a metabolic disease caused by a disruption in the balance between energy production and biosynthesis. The Warburg effect, which involves increased glucose uptake and fermentation of glucose to lactate, is a hallmark of cancer cells and is thought to be essential for their survival and growth. Targeting this pathway has become a promising strategy for treating cancer. This article was authored by Paolo E. Porparato, Rajesh K. Dedeach, Sevira E. Duck and others.