 Conjugative plasminates often carry virulence and antibiotic resistance genes, making them widespread in nature. To understand how they spread, researchers study their behavior within bacterial communities. Bacteria reproduce more slowly when plasminates enter their genomes, which contradicts the plasminate's ubiquity. Several hypotheses exist for why plasminates persist in bacterial populations, but no single explanation has been found. The combination of different bacterial species, strains, and environments makes it difficult to identify a single mechanism for plasmin maintenance. Previous studies have shown that donor cells can outcompete other cells without plasminates due to the presence of conjugated plasminates. Computer simulations confirm this hypothesis with a wide range of parameters. We now show that donor cells still benefit from having plasminates even if compensatory mutations occur in transconjugates. These advantages include the fact that mutations take time to appear, many plasminates remain costly, and retransfer of mutated plasminates usually occurs at distant locations, reducing competition between these cells. Recent decades of research warned against accepting the hypothesis that this article was authored by Joao Esrabello, Celia P. F. Dominguez, and Francisco Denicio. We're article.tv, links in the description below.