 This study investigated whether creatine supplementation could enhance the protective effects of exercise against doxorubicin-induced hepatotoxicity in mice. The results showed that doxorubicin caused hepatotoxicity characterized by increased levels of inflammation, oxidative stress, and fibrotic changes. However, exercise alone partially protected against these effects, and when combined with creatine supplementation, it further enhanced the protective effects of exercise. This suggests that creatine supplementation can be used to potentiate the beneficial effects of exercise on liver health. This article was authored by Lorraine R. L. Costa-Gaudenho, Paula S. Sela, Tatiana A. Esquimares, and others.