 Aging is the leading cause of human deaths. So about 150,000 people die every day across the globe. About 65% of them die of the age-related regions. So that proportion is much higher than higher in the industrialized nations. So there are a number of hypotheses as to why aging occurs. For example, it is programmed by different sets of genes and then DNA damage by, such as radicals in cells. So this aging is very hot topic right now to slow down our aging process. So every organism has different lifespan. So the longest day human has ever been to prudent to live is 122 years. So the case of John Clement. Whereas the lifespan of the wild-time mouse for research purpose is about three years. So the question is why their lifespans are different. So that's very interesting question. So maybe genetic difference between the mouse and human may account for this different aging rates and that they have different efficiency of DNA repair system. And then they are very different in a way to how to metabolize energy. And then they have different rates of renewing cells. And important thing is there is another difference. That is microbiome. Like stars and galaxies in our universe, there are a tremendous number of microbial cells in our body space. So human microbiome consists of 100 trillion microbial cells in our body. Those microbial cells are very important for our health. These are the different pattern, microbial patterns in different human organs. And then they have very different functions in our body. And then they are really closely related with the human disease. For example, the people affected by anxiety disorder, they have an abnormal composition of gut flora. So the gut flora is very important, particularly important. So by doing research on their functional roles, we can characterize the gut flora as a forgotten human organ. There is one possibility raised that is the mammalian immune system is in fact controlled by microorganisms. That's very surprising. The question that we have, the weather of those microbial patterns is changing according to the agent process. So my lab analyzed different microbial patterns is according to agent process. So indeed, microbial patterns of mouths is changing according to agent process. So the microbial patterns of elderly and young individuals have very different proportion of two groups of bacterial cells. That is, those are the bacteria dates and formicutes. Elderly individuals have a high proportion of bacteria dates, whereas the young individuals have high proportion of formicutes. So what is their function in the body? This is the best example. So the gut microflora, they promote the level of serotonin in the body. So serotonin is a signaling molecule that controls diverse body function. They control the gut movement and they control our brain function as well. So this led us to design an experiment which connected two mice to one. And then this experiment enabled us to exchange their bloodstream. Indeed, the microbial patterns of old mouths was drastically changed to the data of young. So that's very interesting and surprising result. Then look at this slide. Then the microbial patterns of old mouths was drastically reversed to the data of young mouths. Then this led us to another experiment, design the another experiment. So we thought there is something in the blood whether that is produced by microbial cells or not that controls the microbial patterns. So we really wanted to find what are those? So this is our another experiment of design. So we injected the blood plasma of young mouths to the old mouths. Then we observed identical results that we observed from the parbiasis experiment. So that was really interesting. So this something in the blood can control the microbial patterns. And then if we can reverse the microbiome, gut microflora from old to young, that means we can reverse our aging process. So taken together, the microbial cells can affect our body functions. And even they can reverse our aging process. They control our brain functions. They control our metabolic functions. And even they can control our aging process. That's very interesting. So here I have a question. Is it really possible to reverse our aging process by controlling gut microbiomes? If so, what are the consequences from that rejuvenation?